In 2006, Dr Zhuang, invented STORM, a super-resolution light microscopy method. The technology allows fluorescent probes to separate the regions of individual molecules that overlap so that the positions of the molecules can be more clearly determined. STORM has allowed Zhuang’s research group, and others, to create three-dimensional fluorescence images of cells and tissues. It is among the most advanced microscopy technologies in the scientific community today. Her research group is currently working on developing imaging capabilities for deep tissues of live animals.
With the remarkable power of STORM microscopy, Dr Zhuang’s lab has actually discovered previously unknown structures inside the axons of neurons. This article describes this discovery.
Nikon Corporation acquired the license for STORM super resolution microscopy from Harvard University, in order to commercialize the N-STORM microscope. Read about this here.
In the images displayed to the left, you can perceive the significant difference in resolution between the STORM images and preceding technologies.